Pre-mRNA Interactions
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Pre-messenger RNA (pre-mRNA) splicing operates as a common mechanism for gene expression regulation in eukaryotes by eliminating introns and connecting exons into mature mRNA. Multiple conserved sequence elements and proteins work together in this complex process which includes splicing factors, RNA helicases and small nuclear ribonucleoproteins (SNRNPs).
The pre-mRNA forms connections with splicing factors via protein-nucleic acid interactions that encompass spliceosome assembly and catalytic reactions followed by product release. Regulatory elements that control these interactions consist of RNA and protein modifications together with RNA binding protein associations.
